Zirconium-Lewis acid was developed to facilitate a de Mayo-type ring expansion reaction in the absence of external photosensitizers and additives. The reaction proceeds through a [2+2] cycloaddition and retro-Aldol sequence between cyclic β-ketocarbonyls and alkenes, which are compatible with various substrates in good yields. Through this strategy, a series of functionalized medium sized-ring skeletons can be constructed starting from readily available starting materials.
Junfeng Wang
,
Ruixuan Liu
,
Xueling Mi
,
Sanzhong Luo
. Zirconium Lewis Acid-Catalyzed de Mayo-Type Ring Expansion of Cyclic β-Dicarbonyls[J]. Chinese Journal of Organic Chemistry, 0
: 202607015
.
DOI: 10.6023/cjoc202607015
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