This study aimed to investigate the chemical components of the traditional medicinal plant Munronia pinnata (Meliaceae). We sought to discover new limonoids and evaluate their biological activities. Compounds were isolated from the plant's aerial parts using 95% ethanol and chromatographic techniques. Their structures were identified by NMR and HRESIMS analysis, along with time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) computations. Cytotoxicity was tested with the CCK-8 assay, and anti-inflammatory activity was measured using the Griess method. A new limonoid, named munropin K (1), was obtained. Its structure features a prieurianin-type skeleton with a unique side chain at C-17. This side chain is a 20,22-dihydroxy-21,23-dimethoxytetrahydrofuran. At 80 µM, the compound showed no significant activity against several human cancer cell lines. These cell lines included A549, HepG2, MCF-7, and HCT116. It also did not show activity in an LPS-induced RAW 264.7 macrophage inflammation model. The research expands the known chemical diversity of the Munronia genus. It provides a chemical basis for future studies on structure modification and activity exploration of this new skeleton.
Yang Xuerong
,
Li Jianxing
,
Yoshiki Kashiwada
,
Naonobu Tanaka
,
Li Dianpeng
. A Novel Prieurianin-Type Limonoid from Munronia pinnata[J]. Chinese Journal of Organic Chemistry, 2026
: 202604025
.
DOI: 10.6023/cjoc202604025
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