SIOC 中文
CJOG
Adv search

Chinese Journal of Organic Chemistry >

0 202604008 - 202604008

DOI: https://doi.org/10.6023/cjoc202604008

ARTICLE

Genome Mining-Based Discovery of Two New Anthraquinone-γ-Pyrones from Streptomyces fragilis

  • Yunfan Wang ,
  • Song You ,
  • Gong-Li Tang ,
  • Xian-Feng Hou
Expand
  • aSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China;
    bShanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), University of CAS, Shanghai 200032, China;
    cSchool of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of CAS, Hangzhou 310024, China

Received date: 2026-05-11

  Revised date: 2026-06-24

  Online published: 2026-09-16

Supported by

National Natural Science Foundation of China (No. 22077134). and the CAS (Youth Innovation Promotion Association 2019257).

Fold

Abstract

Two new anthraquinone-γ-pyrones, fragoquinones A-B (1-2), were discovered from Streptomyces fragilis by overexpression of SARP regulator gene ctg18_196, encoding a cluster-specific positive transcription activator. Their structures were elucidated by analysis of their HRESIMS and NMR spectroscopic data. Preliminary evaluation of antibacterial activity indicated that these two compounds displayed no significant antibacterial effects.

Key words： Genome mining; Streptomyces fragilis; Anthraquinone-γ-pyrones; Structural elucidation; SARP regulator gene

Cite this article

Yunfan Wang , Song You , Gong-Li Tang , Xian-Feng Hou . Genome Mining-Based Discovery of Two New Anthraquinone-γ-Pyrones from Streptomyces fragilis[J]. Chinese Journal of Organic Chemistry, 0 : 202604008 -202604008 . DOI: 10.6023/cjoc202604008

References

[1] Procópio R. E.; Silva I. R.; Martins M. K.; Azevedo J. L.; Araújo J. M.Braz. J. Infect. Dis. 2012, 16, 466-471.
[2] Ikeda H.; Ishikawa J.; Hanamoto A.; Shinose M.; Kikuchi H.; Shiba T.; Sakaki Y.; Hattori M.; Omura S. Nat. Biotechnol.2003, 21, 526-531.
[3] Bentley S. D.; Chater K. F.; Cerdeño-Tárraga A. M.; … Hopwood, D. A. Nature.2002, 417, 141-147.
[4] Bachmann B. O.;Van Lanen, S. G.; Baltz, R. H.J. Ind. Microbiol. Biotechnol. 2014, 41, 175-184.
[5] Nett M.; Ikeda H.; Moore, B. S. Nat. Prod. Rep.2009, 26, 1362-1384.
[6] Zerikly M.; Challis G. L. ChemBiochem.2009; 10, 625-633.
[7] Rutledge P. J.; Challis, G. L. Nat. Rev. Microbiol.2015, 13, 509-523.
[8] Laureti L.; Song L.; Huang S.; Corre C.; Leblond P.; Challis G. L.; Aigle, B. Proc. Natl. Acad. Sci. U. S. A.2011, 108, 6258-6263.
[9] Bibb M. J.Curr. Opin. Microbiol. 2005, 8, 208-215.
[10] Weber T.; Blin K.; Duddela S.; Krug D.; Kim H.U.; Bruccoleri R.; Lee S. Y.; Fischbach M. A.; Müller R.; Wohlleben W.; Breitling R.; Takano E.; Medema, M. H. Nucleic Acids Res.2015, 43, 237-243.
[11] Pan H. X.; Chen Z.; Zeng T.; Jin, W. B; Geng, Y.; Lin G. M.; Zhao J.; Li, W. T; Xiong, Z.; Huang, S. X; Zhai, X.; Liu H. W.; Tang, G. L. Org. Lett.2019, 21, 1374-1378.
[12] Ji Z. Y.; Nie Q. Y.; Yin Y.; Zhang M.; Pan H. X.; Hou X. F.; Tang, G. L. Angew. Chem. Int. Ed.2019, 58, 18046-18054.
[13] Van Cura D.; Ng T. L.; Huang J.; Hager, H. Angew. Chem. Int. Ed.2023, 62, e202304646.
[14] Shikai Y.; Kawai S. Chem. Sci.2023, 14, 8766-8776.
[15] Dong L.; Shen Y.; Hou X. F.; Li W. J.; Tang, G. L. Org. Lett.2019, 21, 2322-2325.
[16] Hou X. F.; Song Y. J.; Zhang M.; Lan W.; Meng S.; Wang C.; Pan H. X.; Cao C.; Tang, G. L. Angew. Chem. Int. Ed.2018, 57, 13475-13479.
[17] Guo W.; Xiao Z.; Huang T.; Zhang K.; Pan H. X.; Tang G. L.; Deng Z.; Liang R.; Lin, S. Microb. Cell Fact.2023, 22, 127.
[18] Murphy B. T.; Narender T.; Kauffman C. A.; Woolery M.; Jensen P. R.; Fenical, W. Aust. J. Chem.2010, 63, 10.1071/CH10068.
[19] Zhou L.; Chen X. Mar. Drugs.2021, 19, 575.
[20] Zhang F.; Roberts C. D.; Lee T. H.; Braun D. R.; Bennett, Z. D. J. Nat. Prod.2025, 88, 2325-2332.
[21] Tietze L.F.; Singidi R.R.; Gericke, K M. Org. Lett.2006, 8, 5873-5876.
Options
Outlines

/

〈 〉