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化学学报
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化学学报 ›› 1958, Vol. 24 ›› Issue (5): 388-390. 上一篇    

论文

对-异菸酰肼磺酰基-苯甲醛缩氨基硫脲的合成

蔡继英, 王以德   

  1. 武汉大学化学系
  • 投稿日期:1958-05-13 发布日期:2013-06-03

SYNTHESES OF p-ISONICOTINYL HYDRAZO-SULFONYL-BENZALDEHYDE THIOSEMICARBAZONE

TSAI CHI-YING, WONG YI-THE   

  1. Department of Chemistry, Wuhan University
  • Received:1958-05-13 Published:2013-06-03

PDF

529

被引次数

5

Domagk于1947年报告氨基硫脲类化合物具抗结核菌性能,并进而找出对-乙酰氨基苯甲醛缩氨基硫脲(p-Acetylaminobenzaldehyde thiosemicarbazone)有强大的抗结核菌效用。其后如TBⅢ等化合物的合成和介绍亦陆续见于文献中。

Syntheses of p-isonicotinyl hydrazo-sulfonyl-benzaldehyde thiosemicarbazone (Ⅱ), which according to strucinre is expected to possess antitubercular property, and its intermediates p-isonicotinyl hdrazo-sulfonyl-benzaldehyde diacetate (Ⅰ) and p-isonicotinyl hydrazo-sslfonyl-beazaldehyde (Ⅲ),are reported in this paper.