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封面介绍Qi, Yunkun & Du, Shanshan et al. on page 341-353: This study developed a “two-step” synthetic strategy that enables efficient preparation of octreotide-doxorubicin conjugates incorporating disulfide-bond linkers. Notably, this work not only provides practical guidelines for solid-phase peptide synthesis (SPPS) of peptide- drug conjugates (PDCs) containing multiple disulfide bonds, but also offers new insights into the design of novel PDCs for targeted cancer therapeutics.
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