化学学报 ›› 1965, Vol. 31 ›› Issue (2): 126-132. 上一篇    下一篇

论文

5-羟基色胺类似物——Ⅲ.若干5-取代的2-二烃胺甲基苯并咪唑之合成

周啓霆, 嵇汝运   

  1. 中国科学院药物研究所
  • 收稿日期:1964-05-19 出版日期:1965-02-15 发布日期:2013-06-03

SEROTONIN ANALOGUES Ⅲ. THE SYNTHESIS OF SEVERAL 5-SUBSTITUTED-2-DIALKYLAMINOMETHYL BENZIMIDAZOLES

CHOW CHI-TING, KYI Zu-YOONG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1964-05-19 Online:1965-02-15 Published:2013-06-03

十二种4-取代的2-硝基-(二烴胺基乙酰)苯胺(Ⅰa-1)在稀醋酸中以次硫酸鈉处理,一步“还原环化”成相应的5-取代的2-二煙胺甲基苯并咪唑(Ⅱa-1).

Twelve 5-substituted-2-dialkylaminomethyl benzimidazoles(Ⅱa-1) have been synthesized by "reductive cyclization" of the corresponding 4-bromo-,chloro-and methoxy-2-nitro-dialkylaminoacetanilides(Ⅰa-1) with sodium hyposulphite in dilute acetic acid.