化学学报 ›› 1965, Vol. 31 ›› Issue (3): 253-257. 上一篇    下一篇

研究简报

γ-芳基-γ-羟基丙胺及其衍生物的合成

童曾寿, 戴昌世   

  • 收稿日期:1964-03-01 出版日期:1965-06-15 发布日期:2013-06-03

SYNTHESIS OF γ-ARYL-γ-HYDROXY-PROPYLAMINES

TUNG TZENG-SHOU, TAI CHANG-SHIH   

  • Received:1964-03-01 Online:1965-06-15 Published:2013-06-03

由于工作中需要γ-芳基-γ-羟基丙胺类化合物,故进行其合成。并在改变其羟基为卤原子时,观察到羟基的消除反应。

γ-Aryl-γ-hydroxy-propylamines have been synthesized as follows:In the presence of polyphosphoric acid,β-phthalimidopropanoic acid (Ⅰ) was condensed with anisol or pyrocatechol dimethylether to give the corresponding aryl (β-phthalimido) propanones(Ⅱ) in good yields.Compounds Ⅱ were hydrolysed to amino-ketones (Ⅲ),which were then reduced to Ⅳ on the one hand,and acetylated to amines Ⅴ on the other hand.When the latter compounds were reduced by sodium borohydride,the corresponding γ-aryl-γ-hydroxy-propylamines (Ⅵ) were obtained.