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化学学报
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化学学报 ›› 1976, Vol. 34 ›› Issue (4): 313-320. 上一篇    下一篇

论文

鹤草酚的全合成

  

  1. 1. 沈阳药学院;
    2. 辽宁省药物研究所合成研究室;
    3. 湖南医药工业研究所
  • 投稿日期:1976-10-09 发布日期:2013-06-03

THE TOTAL SYNTHESIS OF AGRIMOPHOL

  1. 1. SHENYANG PHARMACEUTICAL COLLEGE, CHEMICAL SYNTHETIC LABORATORY;
    2. LIAONING INSTITUTE OF MATERIAL MEDICA;
    3. HUNAN INSTITUTE OF PHARMACEUTICAL INDUSTRIES
  • Received:1976-10-09 Published:2013-06-03

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用伪绵马酚(Ⅵ)、2,4-二甲基-6-(α-甲基丁酰)-间苯三酚(Ⅷ)与甲醛在酸性条件下缩合得到鹤草酚(Ⅰa),因而完全证实了从仙鹤草根芽中分离得到的外消旋驱绦虫有效成分鹤草酚的化学结构.

Agrimophol (Ⅰa) has been obtained by total synthesis from ψ-aspidinol (Ⅵ: R=CH3),2, 4-dimethyl-6-(a-methyl-butyryl)-phlorogluoinol (Ⅷ R=CH3) and formaldehyde in acid condition. Thus, the structure suggested for agrimophol, isolated from the root-sprout of Agrimonia Pilosa Ladeb, in optically inactive form as a taenifuge constituent, is fully substantiated.