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化学学报
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化学学报 ›› 1992, Vol. 50 ›› Issue (12): 1211-1218. 上一篇    

研究论文

两色乌头生物碱的分离和结构测定

陈迪华;斯建勇;常琪;吉川雅之;北川勋   

  1. 中国医学科学院药用植物资源开发研究所;日本国大阪大学药学部
  • 发布日期:1992-12-15

Isolation and structure elucidation of the alkaloids of aconitum alboiolaceum kom

CHEN DIHUA;SI JIANYONG;CHANG QI;JI CHUANYAZHI;BEI CHUANXUN   

  • Published:1992-12-15

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426

被引次数

5

从吉林省抚松县采集的两色乌头(Acomitum albouiolaceum Kom.)的根,分得九种C~10二萜生物碱,其中四种为新化合物:两色乌碱甲(alboviolaconitine A)(1),两色乌碱乙(alboviolaconitine B)(2),两色乌碱丙(alboviolaconitine C)(3)和两色乌碱丁(alboviolaconitine D)(4).其余五种成分鉴定为瑟佩定(septentriodine)(5),牛扁亭(lycaconitine)(6),东乌头定(avadharidine)(7),帕巴乌碱铵(ammoniumpuberaconitine)(8)和牛扁碱 (lycotonine)(9).经分析各种光谱数据及化学方法转为已知物,确定了1-4的结构.

关键词: 生物碱, 红外分光光度法, 质子磁共振谱法, 乌头属, 二萜, 两色乌头甲, 两色乌头乙, 两色乌头丙, 两色乌头丁, 镇痛

Investigation on the alkaloids of roots of A. albo-violaeeum, collected from Fu-song County, Jilin Province in China, has been led to the isolation of nine C19 diterpenoid alkaloids. Four of them are novel natural constituents and named alboviolaconitine A (I), alboviolaconitine B (II), alboviolaconitine C (III) and alboviolaconitine D(IV). Others were septentriodine, lycaconitine, avadharidine, ammonium puberaconitine, and lycoctonine.

Key words: ALKALOID, INFRARED SPECTROPHOTOMETRY, PROTON MAGNETIC RESONANCE SPECTROMETRY, ACONITUM, DITERPENES, ANALGESIA

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