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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (12): 1121-1126. 上一篇    下一篇

研究论文

蛋白质二级结构的氨基酸紧邻位效应和二肽构象因子

吴迪，缪强*，王志林   

  1. (南京大学化学化工学院 南京 210093)
  • 投稿日期:2004-07-16 修回日期:2005-02-21 发布日期:2010-12-10
  • 通讯作者: 缪强

Nearest Neighbor Residue Effect of Amino Acids and the Secondary Structure Conformations of Di-peptide in Proteins

WU Di, MIAO Qiang*, WANG Zhi-Lin   

  1. (Department of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093)
  • Received:2004-07-16 Revised:2005-02-21 Published:2010-12-10
  • Contact: MIAO Qiang

PDF

1151

被引次数

15

提出了蛋白质二级结构中的氨基酸C端和N端邻位因子以及二肽构象因子. 基于对蛋白质数据库PDB105版全库的分析, 讨论了N端和C端邻位对氨基酸二级结构倾向性的影响, 讨论了二肽序的二级结构倾向性. 发现有些氨基酸的邻位因子对和二肽序对的二级结构构象因子差别较大, 表明这些氨基酸对其N端和C端邻位的影响不对称.

关键词: 蛋白质二级结构, 构象因子, 邻位效应, 二肽构象因子

The secondary structure conformations of amino acids were improved, the nearest neighbor residue effect was considered, and the secondary structure conformations of di-peptides were obtained based on the Protein Data Bank (release #105). The neighbor effect differences of C and N terminals as well as the conformation differences of dipeptide order were also discussed.

Key words: protein secondary structure, the conformation of secondary structure, neighbor effect, dipeptide conformation