SIOC English
化学学报
高级检索

化学学报 ›› 2006, Vol. 64 ›› Issue (14): 1513-1516. 上一篇    

研究简报

从猪去氧胆酸甲酯表观合成角鲨多胺

沈季铭，周向东，周维善*   

  1. (中国科学院上海有机化学研究所 上海 200032)
  • 投稿日期:2005-11-24 修回日期:2006-03-24 发布日期:2006-07-28
  • 通讯作者: 周维善

Formal Synthesis of Squalamine from Methylhyodeoxycholanate

SHEN Ji-Ming, ZHOU Xiang-Dong, ZHOU Wei-Shan*   

  1. (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2005-11-24 Revised:2006-03-24 Published:2006-07-28
  • Contact: ZHOU Wei-Shan

PDF

716

被引次数

5 | 2

以猪去氧胆酸甲酯为原料, 经15步反应以总产率5.6%表观合成具有抗菌、抗癌活性的海洋甾体角鲨多胺.

关键词: 角鲨多胺, 猪去氧胆酸甲酯, 表观合成

A marine steroid squalamine with antibacteria and antitumor activity was formally synthesized in 15 steps with 5.6% overall yield from methylhyodeoxycholanate.

Key words: squalamine, methylhyodeoxycholanate, formal synthesis