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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (20): 2295-2300. 上一篇    下一篇

研究论文

两嵌段共聚高分子链通过薄膜上纳米孔隙输运的理论研究

马艳君a   王海军*,a,b,c   顾 芳a,c   

  1. (a河北大学化学与环境科学学院 保定 071002) (b中国科学院国际材料物理中心 沈阳 110016) (c教育部药物化学与分子诊断重点实验室 保定 071002)
  • 投稿日期:2009-01-16 修回日期:2009-05-14 发布日期:2009-06-18
  • 通讯作者: 王海军 E-mail:whj@mail.hbu.cn
  • 基金资助:

    国家自然科学基金No.20873035

Translocation of a Diblock Copolymer Chain through a Nanopore in a Membrane

Ma, Yanjuna   Wang, Haijun*,a,b,c    Gu, Fang a,c   

  1. (a College of Chemistry and Environmental Science, Hebei University, Baoding 071002) (b International Center for Materials Physics, Chinese Academy of Sciences, Shenyang 110016) (c Education Ministry Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Hebei University, Baoding 071002)
  • Received:2009-01-16 Revised:2009-05-14 Published:2009-06-18

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针对两嵌段高分子链的跨膜输运过程, 分别给出与不同输运次序相对应的高分子链的自由能, 进而通过求解Fokker-Planck方程并在不同条件下对平均首次通过时间进行了数值计算. 计算结果表明, 当共聚高分子链由良溶剂区向不良溶剂区输运时, 不能发生线团-链滴转变的链首先输运总是有利于整个高分子链的输运. 而在给定输运次序的情况下, 化学势、线团-链滴转变、共聚链的组成以及输运速率等因素对输运时间可产生显著影响. 相关研究结果可为调控实际生物高分子链的输运时间提供可能的理论线索.

关键词: 两嵌段共聚高分子链, 跨膜输运, 平均首次通过时间, 线团-链滴转变

For the translocation of a diblock copolymer chain through a nanopore on a membrane with two translocation orders, the free energies under different conditions are given, and then the mean first-passage time (MFPT) is obtained by solving the Fokker-Planck equation. By the corresponding numerical calculations, it is shown that, when the copolymer chain transports from the region of good solvent to that of poor solvent, the translocation order that the block without coil-blob transition transports first is prior to the other. At a given order, it is found that the chemical potential, coil-blob transition, composition of the diblock copolymer chain and the translocation rate play an important role in the translocation. The present studies are expected to provide available clues for the translocation of real biopolymer chain.

Key words: diblock copolymer chain, translocation, mean first-passage time (MFPT), coil-blob transition

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