化学学报 ›› 2009, Vol. 67 ›› Issue (8): 843-849. 上一篇    下一篇

研究论文

多重响应性介孔二氧化硅纳米微球的制备及载药研究

刘聪颖 胡建华* 杨 东 杨武利*

  

  1. (复旦大学高分子科学系 聚合物分子工程教育部重点实验室 上海 200433)

  • 收稿日期:2009-03-12 修回日期:2009-03-30 出版日期:2009-04-28 发布日期:2009-04-28
  • 通讯作者: 胡建华

Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release

Liu, Congying Hu, Jianhua* Yang, Dong Yang, Wuli*

  

  1. (Education Ministry Key Laboratory of Molecular Engineering of Polymer, Department of Macromolecular Science,
    Fudan University, Shanghai 200433)
  • Received:2009-03-12 Revised:2009-03-30 Online:2009-04-28 Published:2009-04-28
  • Contact: Hu Jian-Hua

采用溶胶凝胶法制备了以油酸稳定的Fe3O4为核, 十六烷基三甲基溴化铵(CTAB)为模板剂的磁响应性的介孔二氧化硅纳米微球; 通过孔道内修饰羧基和巯基, 链转移反应修饰线性的聚(N-异丙基丙烯酰胺-co-N-羟甲基丙烯酰胺)共聚物得到多重响应性的介孔二氧化硅纳米微球P(NIPAM-co-NHMA)@M-MSN(-COOH). 利用Brunauer-Emmett-Teller (BET)、振动样品磁强计(VSM)、透射电子显微镜(TEM)、紫外光谱(UV/Vis)表征了微球的物理化学性质. 阿霉素(DOX)被用作模型药物研究了这种多重响应性的介孔二氧化硅纳米微球作为药物载体的载药及药物释放行为, 结果显示这种纳米微球载药率高达48%, 药物释放呈现对温度和pH的双重响应性, 可以实现对药物的控制释放.

关键词: 多重响应性, 介孔二氧化硅, 载药, 控制释放

Magnetic mesoporous silica nanoparticles (M-MSN) were prepared via sol-gel technology with oil stabilized Fe3O4 as the core and cetytrimethylammonium bromide (CTAB) as the template. Then P(NIPAM-co-NHMA) copolymer was modified to the magnetic mesoporous silica nanoparticles to prepare a kind of multi-responsive mesoporous silica microspheres, P(NIPAM-co-NHMA)@M-MSN(-COOH), through chain transfer reaction. Brunauer-Emmett-Teller (BET), vibrating-sample magnetometer (VSM), transmission electron microscopy (TEM) and UV/vis spectra were used to characterize the multi-responsive microspheres. DOX was used as a model drug to measure the drug loading and controlled drug releasing properties. The result indicated that the multi-responsive microspheres exhibited an excellent drug loading capacity of 48% and controlled drug releasing could be obtained by changing the temperature and pH values.

Key words: multi-responsive, mesoporous silica, drug loading, controlled drug releasing