化学学报 ›› 2014, Vol. 72 ›› Issue (12): 1218-1222.DOI: 10.6023/A14080600 上一篇    下一篇

研究论文

荧光无机/有机杂化纳米分子口袋的构建

杨慧, 刘礼兵, 张洲, 薛峥, 李勇军, 王树, 刘辉彪   

  1. 中国科学院化学研究所有机固体院重点实验室 北京分子科学国家实验室 北京100190
  • 投稿日期:2014-08-25 发布日期:2014-12-09
  • 通讯作者: 刘辉彪 E-mail:liuhb@iccas.ac.cn
  • 基金资助:

    项目受国家自然科学基金(Nos.21373235,21031006)和国家重点基础研究计划(Nos.2011CB932302,2011CB932303)资助.

Constructing High Luminescent Inorganic/Organic Hybrid Nanoscale Molecular Pockets

Yang Hui, Liu Libing, Zhang Zhou, Xue Zheng, Li Yongjun, Wang Shu, Liu Huibiao   

  1. CAS Key Laboratory of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2014-08-25 Published:2014-12-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21373235, 21031006) and the National Basic Research Program of China (Nos. 2011CB932302, 2011CB932303).

利用能量匹配原则将无机半导体ZnO纳米粒子与有机半导体四苯基卟啉四羧酸(TCPP)分子进行组装, 在无机-有机组分之间的界面构建了杂化纳米分子口袋ZNPs-TCPP, 该纳米分子口袋对四苯基卟啉(TPP)分子具有高选择性识别功能, 同时其荧光增强了5倍以上, 并成功地将该杂化纳米分子口袋用于肺腺癌细胞(A549)的细胞成像.

关键词: 纳米分子口袋, 卟啉, 无机/有机杂化, 细胞成像

An inorganic/organic hybrid nanoscale molecular pocket ZNPs-TCPP was constructed through the assembly of 5,10,15,20-tetra(3-carboxyphenyl) porphyrin (TCPP) on the surface of ZnO nanoparticles (NPs), which highly selectively recognized 5,10,15,20-tetraphenylporphyrin (TPP) molecule. The resulting hybrid nanoscale molecular pockets ZNPs-TCPP captured TPP demonstrated high emission efficiency and the intensity of its emission was five times greater than that of ZnONPs-TCPP. Significantly, the molecular pocket ZNPs-TCPP-TPP with high luminescence can be dispersed in water and is successfully applied for the cell imaging of A549.

Key words: nanoscale molecular pockets, porphyrin, inorganic/organic hybrid, cell imaging