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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (8): 853-859. 上一篇    下一篇

研究论文

嵌段共聚物PDMAEMA-b-PCL的合成、修饰及其水溶液性质研究

姚加，翟韬，童达君，李浩然*   

  1. 浙江大学 浙江大学 浙江大学 浙江大学化学系
  • 投稿日期:2007-09-30 修回日期:2007-11-16 发布日期:2008-04-28
  • 通讯作者: 李浩然

Synthesis, Modification and Aqueous Properties of a Diblock Copolymer: PDMAEMA-b-PCL

YAO Jia ZHAI Tao TONG Da-Jun LI Hao-Ran*   

  1. (Department of Chemistry, Zhejiang University, Hangzhou 310027)
  • Received:2007-09-30 Revised:2007-11-16 Published:2008-04-28
  • Contact: LI Hao-Ran

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通过甲基丙烯酸N,N-二甲氨基乙酯(dimethylamino ethyl methacrylate)和环己内酯(ε-caprolactone)之间的连续阴离子聚合, 合成了末端含有氨基的聚甲基丙烯酸N,N-二甲氨基乙酯-嵌段-聚己内酯的双亲性嵌段共聚物(PDMAEMA-b-PCL). 为了增强生物相容性, 通过末端氨基与D-葡萄糖酸内酯(D-gluconolactone)的酰胺化反应对该共聚物进行糖基修饰. 合成的共聚物的化学结构用氢核磁共振光谱(1H NMR)和红外光谱(IR)进行表征, 聚合物的分子量分布采用凝胶色谱(GPC)测定, 该嵌段共聚物在水溶液中的自组装行为则借助于动态光散射(DLS)进行了研究.

关键词: 聚甲基丙烯酸N,N-二甲氨基乙酯-嵌段-聚己内酯, 阴离子聚合, 双亲性嵌段共聚物

A poly[(dimethylamino)ethyl methacrylate]-block-poly(ε-caprolactone) copolymer (PDMAEMA- b-PCL) bearing a sugar moiety at the PDMAEMA end was synthesized via a sequential anionic polymerization of dimethylamino ethyl methacrylate (DMAEMA) and ε-caprolactone (ε-CL), followed by a coupling reaction with D-gluconolactone. The structure of the polymer was confirmed by 1H NMR spectroscopy, IR and gel permeation chromatography. The self-assembly behavior of this polymer in aqueous solution was studied by using dynamic light scattering.

Key words: G-PDMAEMA-b-PCL, anionic polymerization, amphiphilic diblock copolymer