Abstract：A novel method to prepare mesoporous MgAl2O4 coating on the honeycomb cordierite ceramics from only inorganic salt and alkali by the generalized Lewis acid-base theory was reported. The Pt-based monolithic catalysts were prepared successfully after CexZr1-xO2 modified and Pt loaded by in-situ acid-alkali reaction. The samples were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), and N2-sorption. The results showed that the coating had uniform microcrystal structure as well as high surface area (>250 m2穏-1) and large pore volume (0.32 cm3穏-1). The investigations of H2 catalytic combustion showed these monolithic catalysts could fastly start up even at room temperature, and H2 initial conversion could reach more than 95%.