化学学报 ›› 2012, Vol. 0 ›› Issue (04): 499-504.DOI: 10.6023/A1105167 上一篇    下一篇

研究论文

含氮杂冠醚双亲聚合物纳米球的制备及性能

张瑀健a, 谢彬a, 张丽洋a, 马丽a, 何书艳a, 李国文b   

  1. a 中国石油大庆化工研究中心 大庆 163714;
    b 吉林大学超分子材料与结构国家重点实验室 长春 130012
  • 收稿日期:2011-05-16 修回日期:2011-08-15 出版日期:2012-02-28 发布日期:2011-09-28
  • 通讯作者: 张瑀健
  • 基金资助:

    国家自然科学基金(No. 20874037)资助项目.

Preparation and Properties of Amphiphilic Polymer Nanospheres Containing Aza-crown ether

Zhang Yujiana, Xie Bina, Zhang Liyanga, Ma Lia, He Shuyana, Li Guowenb   

  1. a Daqing Petrochemical Research Center, Daqing 163714;
    b State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012
  • Received:2011-05-16 Revised:2011-08-15 Online:2012-02-28 Published:2011-09-28
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20874037).

设计、合成了含氮杂冠醚和腺嘌呤的双亲聚合物, 聚[N,N-二乙氧基-1,10-二氮杂-18 冠-6-5-甲基-腺嘌呤-异酞酸酯] (PCASE). SEM 观测到在水溶液中该聚合物与5-氟尿嘧啶(5-flu)小分子识别后自发聚集成直径约140~210 nm 的纳米球, 用动态光散射测得水溶液中PCASE/5-flu 纳米球的粒径主要集中在120~230 nm 范围内, FTIR 研究了PCASE/ 5-flu 纳米球内聚合物PCASE 中腺嘌呤与底物5-氟尿嘧啶的分子识别, 结果表明, 识别后5-氟尿嘧啶环上C(2)=O 伸缩振动峰从1724 cm-1 位移至1718 cm-1, 且聚合物中腺嘌呤NH2 峰3324 cm-1 消失, 出现了一个新的NH2 峰3432 cm-1, 说明5-氟尿嘧啶环上C(2)=O 与聚合物PCASE 中腺嘌呤上NH2 间形成了氢键. 变温红外谱显示, 识别后的羰基峰1718 cm-1 随温度的升高逐渐向高波数回移, 并最终稳定在5-氟尿嘧啶环上C(2)=O 识别前的1724 cm-1 处, 且识别后产生的新NH2 峰3432 cm-1 随温度的升高逐渐减弱至消失, 表明所形成的氢键断裂.

关键词: 双亲聚合物, 氮杂冠醚, 自组织, 分子识别

An amphiphilic polymer containing adenine and aza-crown ethers, poly-{[N,N-bis(2-ethoxy)-1,10-diaza-18-crown-6][5-methylene-(1-adenine)]sophthaloyl ester} (PCASE), was synthesized. The SEM morphology observed indicates that the amphiphilic PCASE polymer self-organized into diameters of about 140~210 nm nanospheres in dilute aqueous solution after recognized with 5-fluorouracil spontaneously. The sizes of PCASE/5-flu nanospheres in dilute aqueous solution determined by dynamic light scattering (DLS) are mainly dispersed at 120~230 nm. The molecule recognition based on hydrogen bond between adenine of polymer and 5-fluorouracil substrate in PCASE/5-flu nanospheres was studied. After recognition the C(2)=O stretching vibration at 1724 cm-1 of 5-fluorouracil subtract shifted to 1718 cm-1, the NH2 stretching vibration at 3324 cm-1 disappeared, and a new peak at 3432 cm-1 arised, indicating the formation of hydrogen bonds between 5-fluorouracil and adenine in polymer PCASE.The study on variable temperature FTIR show that the peak 1718 cm-1 gradually shifted back to the position at 1724 cm-1, and the new peak 3432 cm-1 disappeared finally, indicating that the H-bond was broken.

Key words: amphiphilic polymer, aza-crown ether, self-organization, molecular recognition