化学学报 ›› 2013, Vol. 71 ›› Issue (02): 147-150.DOI: 10.6023/A12121037 上一篇    下一篇

研究亮点

氧化偶联策略在复杂吲哚生物碱全合成中的应用

张丹a, 秦勇a,b   

  1. a 重庆大学创新药物研究中心 化学化工学院 重庆401331;
    b 四川大学 华西药学院 成都610041
  • 投稿日期:2012-12-11 发布日期:2013-01-04
  • 通讯作者: 秦勇 E-mail:qinyong@cqu.edu.cn
  • 基金资助:

    项目受科技部973计划(No. 2010CB833200);国家自然科学基金(Nos. 21202209, 21132006);中央高校基本科研业务费(CQDXWL-2012-131)以及重庆市自然科学基金(No. cstc2012jjA10087)资助.

Oxidative Coupling Strategy in the Total Syntheses of Complex Indole Alkaloids

Zhang Dana, Qin Yonga,b   

  1. a The Innovative Drug Research Centre and School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331;
    b West China School of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2012-12-11 Published:2013-01-04
  • Supported by:

    Project supported by National Basic Research Program of China (973 program, No. 2010CB833200), the Natural Science Foundation of China (Nos. 21202209, 21132006), the Fundamental Research Funds for the Central Universities (CQDXWL-2012-131), and the Natural Science Foundation Project of CQ CSTC (No. cstc2012jjA10087).

氧化偶联反应作为一种高效、经济的C—C键构建策略, 在天然产物的全合成中得到了重要的应用. 近年来, 马大为课题组通过发展高效的LiHMDS/I2偶联条件, 成功实现了四种复杂吲哚生物碱的全合成, 在该领域取得了重要的进展. 本文就马大为课题组近年在该领域的工作作一亮点评述.

关键词: 氧化偶联, communesin F, communesin A~B, vincorine, 全合成

Oxidative coupling as a highly efficient and economic strategy for carbon-carbon bond formation has been applied in the total syntheses of natural products. Recently, Ma’s group achieved the total syntheses of four complex indole alkaloids by developing a highly versatile LiHMDS/I2 oxidative coupling condition, which merits an important progress in this filed. In this highlight, recent progress of Ma’s group is reviewed.

Key words: oxidative coupling, communesin F, communesin A~B, vincorine, total synthesis