化学学报 ›› 2013, Vol. 71 ›› Issue (04): 493-500.DOI: 10.6023/A13010088 上一篇    下一篇

综述

组合化学在开发纳米材料以及纳米生物医学研究中的应用进展

吴金梅, 苏高星, 张斌, 闫兵   

  1. 山东大学化学与化工学院 济南 250100
  • 收稿日期:2013-01-17 出版日期:2013-04-14 发布日期:2013-03-01
  • 通讯作者: 闫兵 E-mail:drbingyan@yahoo.com
  • 基金资助:

    项目受国家重点基础研究发展计划(973计划)项目(No. 2010CB933504)和国家自然科学基金(Nos. 21137002, 21077068)资助.

Nanocombinatorial Chemistry in Nanomaterial Discovery and Nanomedicine

Wu Jinmei, Su Gaoxing, Zhang Bin, Yan Bing   

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2013-01-17 Online:2013-04-14 Published:2013-03-01
  • Supported by:

    Project supported by the National Basic Research Program of China (973 Program, No. 2010CB933504) and the National Natural Science Foundation of China (Nos. 21137002, 21077068).

组合化学是一种将计算机辅助设计、有机化学合成以及高通量筛选一体化的技术. 它以高效、微量、高度自动化的特点而受到世人瞩目, 对药物研发中加速寻找先导化合物起到了极大的推进作用. 近年来随着纳米技术的迅速发展, 组合化学策略和高通量技术也在此领域中得到应用. 为在今后的研究中能够更好地将组合化学技术应用于纳米材料和纳米技术研究领域, 本文综述了组合化学在开发新型纳米材料以及通过对纳米材料进行表面化学修饰来提高其在生物医学领域的应用研究进展, 并对目前应用于纳米技术研究的高通量筛选技术, 如磁共振成像、自动化基因芯片系统和荧光激活细胞分类术以及对纳米组合化学目前遇到的一些挑战进行了简单概括, 并对其未来的发展趋势提出了展望.

关键词: 组合化学, 高通量筛选, 纳米材料, 纳米医学, 纳米组合化学

Combinatorial chemistry is a scientific technology covering computational chemistry, organic synthesis, and high-throughput screening. Combinatorial chemistry can achieve synthesis and screenings of large compounds within a short time, which can greatly improve compounds synthesis efficiency, shorten compounds discovery cycle and reduce cost effectively. It has greatly impacted on lead compounds discovery with high efficiency, miniaturization and high automation. In recent years, combinatorial chemistry was not only applied in drugs discovery, but also applied in catalyst discovery, pesticide discovery and polymer discovery because of its advantages. With the rapid development of nanotechnology, combinatorial chemistry strategies and high throughput technologies have been introduced to this area. The development of nanotechnology will have tremendous impacts on every aspect of our society. However, it requires a time-consuming research effort on the discovery and optimization of novel nanomaterials with unique properties. Parallel reactions and high-throughput screening are considered to be more efficient than conventional linear operations. In addition, combinatorial chemistry can achieve the biological activities variety of nanomaterials by modifying nanomaterials surface. In this review, we summarized the applications of nanocombinatorial chemistry in the discovery of novel nano materials and the discovery of medicines with modified nanomaterials. We also summarized many high-throughput screening technologies which were used in nanotechnology research, including magnetic resonance imaging (MRI), automation gene chip system and fluorescent activated cell sorter (FACS). Finally, for easily understanding the tendency of nano-combinatorial chemistry, some challenges and future perspectives of nanocombinatorial chemistry were also included.

Key words: combinatorial chemistry, high-throughput screening, nanomaterial, nanomedicine, nanocombinatorial chemistry