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化学学报
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化学学报 ›› 1980, Vol. 38 ›› Issue (3): 275-282. 上一篇    下一篇

论文

农抗101-己及庚的分离及结构

华家柽, 谢毓元   

  1. 中国科学院上海药物研究所
  • 投稿日期:1978-06-16 发布日期:2013-06-03

THE ISOLATION AND STRUCTURE OF ANTIBIOTICS NONGKANG 101-F AND G

HUA JIA-CHENG, XIE YU-YUAN   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1978-06-16 Published:2013-06-03

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2

农抗101是从制霉菌素产生菌金色链霉菌A-94菌株发酵液中得到的抗真菌油状物.经逆流分溶和分部结晶等方法从农抗101中分到了八个成分,农抗101-己及庚为其中两个成分.经元素分析、紫外光谱、红外光谱、核磁共振及质谱等分析,证明农抗101-己的结构为β-氨甲酰甲基-γ-(2-羟基-3,5-二甲基苯甲酰)-丁内酯;农抗101-庚的结构为β-[(2-羟基-3,5-二甲基苯甲酰)羟甲基]-戊二酰亚胺.

Nong-Kang 101-F and G have been isolated from Nong-kang 101, a crute egtraot from the culture broth of Streptomyces aureus A-94, by countercurrent distribution. Based on elemental analyses, UV, IR, NMR and MS spectra the structures of Nong-kang 101-F and G are assigned as β-carbamylmethyl-γ-(2-hydrogy-3,5-dime-thylbenzoyl) butyrolactone and β-[(2-hydrozy-3, 5-dimethylbenzoyl) hydroxymethyl] glutarimide respectively.