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化学学报
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化学学报 ›› 1979, Vol. 37 ›› Issue (2): 119-128. 上一篇    下一篇

论文

猫眼草化学成分的研究

尚天民1, 王琳1, 梁晓天1, 林秀英2, 萧进明2, 牛守谦3   

  1. 1. 中国医学科学院药物研究所;
    2. 保定地区药品鉴定所;
    3. 河北省药品鉴定所
  • 投稿日期:1978-02-21 发布日期:2013-06-03

STUDIES ON THE CONSTITUENTS OF MAO-YAN-CAO(EUPHORBIA LUNULATA BGE.)

SHANG TIAN-MIN1, WANG LIN1, LIANG HSIAO-TIEN1, LIN XIU-YING2, XIAO JIN-MING2, NIU SHOU-LIAN3   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences
  • Received:1978-02-21 Published:2013-06-03

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1088

被引次数

11

猫眼草(Euphorbia Lunulata Bge.)是民间治疗慢性气管炎的一种草药.为阐明其有效成分,提高疗效,对猫眼草进行了化学成分的研究.利用硼砂-乙酸乙酯,聚酰胺柱层析等方法,分离到六种结晶(Ⅰ～Ⅵ).经红外光谱、紫外光谱、质谱与核磁共振谱等分析及物理化学常数的测定,鉴定出其中五种结晶(Ⅰ～Ⅴ)分别为3,5,7,4'-四羟基黄酮(山萘酚),3,5,7,3',4'-五羟基黄酮(槲皮素),山萘酚-3-单-L-鼠李糖甙,槲皮素-3-单-L-鼠李糖甙,与6,7-双羟基香豆精.Ⅵ是新化合物,其结晶经测定证明亦属香豆精类,命名为猫眼草素(Maoyancaosu).

Mao-Yan-Cao(Euphorbia Lunulata Bge.),a Chinese herb, has beneficial effect in the treatment of chronic bronchitis. Six crystalline compounds have been isolated from Mao-Yan-Cao by polyamide column chromatography and borax-ethyl acetate extracting method. Through spectroscopic analyses (UV, IR, NMR, MS) and the determination of physico-chemical constants, five of them have been identified as 3,5,7,4'-tetrahydroxyflavone (kaemperol),3,5,7,3',4'-pentahydroxyflavone(quercetin), kaompferol-3-mono-L-rhammoside, quercetin-3-mono-L-rhammoside and 6,7-dihy-droxycourmarin respectively. The sixth component is a new ooumarin derivative, named Maoyancaosu to which structure VI is tentatively assigned.