化学学报 ›› 2019, Vol. 77 ›› Issue (10): 951-963.DOI: 10.6023/A19040127    下一篇

综述

基于纳米间隔电极对的DNA分子结电输运的研究进展

杨威宇a, 雷志超b, 洪文晶b*(), 黄飞舟a*()   

  1. a 中南大学 湘雅三医院 长沙 410013
    b 厦门大学 化学化工学院 厦门 361005
  • 收稿日期:2019-04-11 出版日期:2019-10-15 发布日期:2019-05-21
  • 通讯作者: 洪文晶,黄飞舟 E-mail:whong@xmu.edu.cn;huangfeizhou@csu.edu.cn
  • 作者简介:杨威宇, 男, 中南大学湘雅三医院在读硕士生. 2017年于中南大学湘雅医学院临床医学系获医学学士学位. 主要从事肝胆疾病生物标志物的前沿检测技术以及生物分子的电输运性质的研究.|雷志超, 男, 固体表面物理化学国家重点实验室科研助理. 2012年于厦门大学化学化工学院化学生物学系获理学学士学位, 2018年于厦门大学化学系获理学博士学位. 主要从事催组装、分子伴侣、染色质折叠和调控等方面的研究.|洪文晶, 男, 教授, 博士生导师. 2013年于伯尔尼大学化学与生物化学系获博士学位, 2017年获国家优秀青年科学基金资助. 现担任厦门大学化学化工学院教授委员会副主任, 化学工程与生物工程系系主任. 主要研究方向包括: 单分子尺度研究; 精密科学仪器研发; 人工智能的工业应用. 已在Acc. Chem. Res.Chem. Soc. Rev.Nat. Mater.等国际学术期刊上发表SCI收录论文50余篇.|黄飞舟, 男, 教授, 博士生导师, 一级主任医师, “湘雅名医”入选者, 中南大学湘雅三医院副院长. 现担任湖南省医学会常务理事、门静脉高压症专业学组组长. 主要研究方向包括: 门静脉高压症的发病机制及治疗策略; 肝癌的早期诊断及手术干预方式; 肝脏缺血再灌注损伤的发病机制及防治方法. 已在国际学术期刊上发表SCI收录论文30余篇, 主持省部级课题5项, 获省部级科技进步奖2项.
  • 基金资助:
    项目受中南大学湘雅三医院“新湘雅人才工程”(20150203);国家重点研发计划(2017YFA0204902);国家自然科学基金(21722305)

Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation

Yang, Wei-Yua, Lei, Zhi-Chaob, Hong, Wenjingb*(), Huang, Fei-Zhoua*()   

  1. a Third Xiangya Hospital, Central South University, Changsha 410013
    b College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
  • Received:2019-04-11 Online:2019-10-15 Published:2019-05-21
  • Contact: Hong, Wenjing,Huang, Fei-Zhou E-mail:whong@xmu.edu.cn;huangfeizhou@csu.edu.cn
  • Supported by:
    Project supported by the New Xiangya Talent Project of the Third Xiangya Hospital of Central South University(20150203);the National Key R&D Program of China(2017YFA0204902);the National Natural Science Foundation of China(21722305)

脱氧核糖核酸分子是一类重要的生物分子, 在生物医学领域之外, 该类分子还因为其所具有的独特的双螺旋结构以及长程输运能力, 在分子电子学领域也引起了研究者的极大兴趣. 本文综述了近年来基于纳米间隔电极对构筑分子结这一研究范式, 在构筑脱氧核糖核酸分子结以及研究后者的电输运性质等方面的研究进展. 依据研究者所采用的不同纳米间隔电极对构筑技术, 主要围绕裂结法和切割法两大类研究方法所展开. 前者主要包括扫描隧道显微镜裂结法、导电原子力显微镜法、机械可控裂结法, 后者则主要包括碳纳米管切割法、石墨烯切割法、硅纳米线切割法. 在梳理不同实验方法的发展脉络、比较不同实验方法的各自特点的基础上, 对一些具有代表性的关于脱氧核糖核酸分子结的研究工作进行了重点介绍, 探讨了脱氧核糖核酸分子结所具有的与常规小分子体系所不同的特殊电学性质, 同时对该领域的未来发展进行了展望.

关键词: 分子电子学, 分子结, 脱氧核糖核酸, 电输运

Molecular electronics is an interdisciplinary science that mainly studies the charge transport through molecules and its main goal is to fabricate molecular devices with electrical functionalities. In the state-of-art of molecular electronics, the research paradigm is to fabricate electrodes pair with nanometer-sized separation and construct the molecular junction through the assembly of target molecules with the electrodes pair. With this framework, the target molecule can be integrated to the macroscopic measurement circuit. DNA is one of the most significant biomolecules in natural sciences. It had drawn great attentions in biomedicine because of the carried genetic instructions. In molecular electronics, DNA also had attracted much interest due to the distinct structure and its capability of long-range charge transport. Nevertheless, in the early stage of molecular electronics, the probe molecules were limited to those with simple structures and short lengths. In recent years, molecular electronics had witnessed a rapid progress due to the developments in micro/nano-fabrication and the detection for weak current signal. Specifically, it includes the improvements in the success rate, efficiency, and stability of the fabricated molecular device. Benefiting from that, the probe molecules had been extended to a number of complex compounds like DNA. We give a brief introduction to the recent progress in the fabrication of DNA molecular junctions and the studies on the corresponding charge transport, most of which were made by using the research paradigm of fabricating electrodes pair with nanometer-sized separation. According to the fabrication methods that employed, these advances were introduced in two classes. One is that made by the as-called break junction methods, which include STM-break junction, conductive AFM and mechanically controllable break junction. The other is that made by the as-called cutting methods, which include cutting of carbon nanotube, graphene and silicon nanowire. We summarize the historical development of these methods and give a comparison between them. We also introduce some representative research on the charge transport through DNA molecular junction, and discuss the distinct features of DNA in electrical properties compared to the conventional small molecules. To conclude, we give a prospect on the future development of the studies on charge transport through DNA molecular junction.

Key words: molecular electronics, molecular junction, DNA, charge transport