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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (23): 2755-2761.DOI: 10.6023/A1104071     Next Articles

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磷酰胆碱基pH敏感性ABA型嵌段共聚物的合成与胶束化

党莉, 刘守信*, 杨曦, 齐晓君, 王红梅, 吕海燕, 田荣   

  1. (应用表面与胶体化学教育部重点实验室 陕西师范大学化学与材料科学学院 西安 710062)
  • 投稿日期:2011-04-07 修回日期:2011-07-27 发布日期:2011-08-15
  • 通讯作者: 刘守信 E-mail:liushx@snnu.edu.cn
  • 基金资助:

    磷酰胆碱基ABA型嵌段共聚物胶束的聚电解质交联

Synthesis and Micellization of Phosphorylcholine-Based pH-Responsive Triblock Copolymers

DANG Li, LIU Shou-Xin, YANG Xi, QI Xiao-Jun, WANG Hong-Mei, LV Hai-Yan, TIAN Rong   

  1. (Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xian 710062)
  • Received:2011-04-07 Revised:2011-07-27 Published:2011-08-15

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ABA triblock copolymer [A＝2-(diethylamino)ethylmethacrylate], DEAEMA|B＝2-methacryloyloxyethyl phosphorylcholine, MPC] (PDEAEMA-b-PMPC-b-PDEAEMA) was synthesized via atom transfer radical polymerization (ATRP) in methanol using CuBr/2,2-bipyridyl as the catalyst system and diethyl-meso-2,5-dibromoadipate as the initiator. PDEAEMA-b-PMPC-b-PDEAEMA was characterized by 1H NMR and GPC. The pH sensitivity of the triblock copolymer aqueous solutions was investigated by transmittance and viscosity measurements. The micellization of the triblock copolymer aqueous solutions was investigated by surface tension measurements, fluorescence probe and transmission electron microscope. The results show that the resultant block copolymer has pH sensitivity, the critical phase change pH was 7～7.5, “flower micelle” can be formed through adjusting solution pH, and the critical micelle concentration (CMC) of the triblock copolymer aqueous solution was measured.

Key words: 2-methacryloyloxyethyl phosphorylcholine (MPC), pH-sensitivity, 2-(diethylamino)ethyl methacrylate (DEAEMA), atom transfer radical polymerization (ATRP), block copolymer