Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (02): 147-150.DOI: 10.6023/A12121037 Previous Articles     Next Articles



张丹a, 秦勇a,b   

  1. a 重庆大学创新药物研究中心 化学化工学院 重庆401331;
    b 四川大学 华西药学院 成都610041
  • 投稿日期:2012-12-11 发布日期:2013-01-04
  • 通讯作者: 秦勇
  • 基金资助:

    项目受科技部973计划(No. 2010CB833200);国家自然科学基金(Nos. 21202209, 21132006);中央高校基本科研业务费(CQDXWL-2012-131)以及重庆市自然科学基金(No. cstc2012jjA10087)资助.

Oxidative Coupling Strategy in the Total Syntheses of Complex Indole Alkaloids

Zhang Dana, Qin Yonga,b   

  1. a The Innovative Drug Research Centre and School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331;
    b West China School of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2012-12-11 Published:2013-01-04
  • Supported by:

    Project supported by National Basic Research Program of China (973 program, No. 2010CB833200), the Natural Science Foundation of China (Nos. 21202209, 21132006), the Fundamental Research Funds for the Central Universities (CQDXWL-2012-131), and the Natural Science Foundation Project of CQ CSTC (No. cstc2012jjA10087).

Oxidative coupling as a highly efficient and economic strategy for carbon-carbon bond formation has been applied in the total syntheses of natural products. Recently, Ma’s group achieved the total syntheses of four complex indole alkaloids by developing a highly versatile LiHMDS/I2 oxidative coupling condition, which merits an important progress in this filed. In this highlight, recent progress of Ma’s group is reviewed.

Key words: oxidative coupling, communesin F, communesin A~B, vincorine, total synthesis