Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (05): 717-721.DOI: 10.6023/A13020198 Previous Articles     Next Articles


钯催化下肟醚导向的sp2 C—H键邻位酰氧化反应

蔡海婷, 李丹丹, 刘姿, 王官武   

  1. 中国科学技术大学化学系 合肥微尺度物质科学国家实验室 合肥 230026
  • 投稿日期:2013-02-19 发布日期:2013-03-21
  • 通讯作者: 王官武,; Tel.: 0551-63607864; Fax: 0551-63607864
  • 基金资助:

    项目受国家自然科学基金(No. 91021004)和安徽省高校省级自然科学研究重大项目(No. KJ2010ZD05)资助.

Palladium-Catalyzed Decarboxylative ortho-Acylation of O-Methyl Ketoximes via Direct sp2 C—H Bond Activation

Cai Haiting, Li Dandan, Liu Zi, Wang Guanwu   

  1. Department of Chemistry and Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230026
  • Received:2013-02-19 Published:2013-03-21
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 91021004) and the Intercollegiate Key Project of Natural Sciences of Anhui Province, China (No. KJ2010ZD05).

The palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-oxocarboxylic acids in the presence of Na2S2O8 and Ag2O is demonstrated. This protocol can be applied to various O-methyl ketoximes and α-oxocarboxylic acids with both electron-donating and electron-withdrawing groups with products yields up to 98%.

Key words: palladium catalysis, C—H bond activation, O-methyl ketoximes-directed, decarboxylation, acylation