Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (08): 1091-1100.DOI: 10.6023/A13030279 Previous Articles     Next Articles

Review

金属配合物/手性磷酸参与的不对称接力催化反应

吴祥, 李明丽, 龚流柱   

  1. 合肥微尺度物质科学国家实验室 中国科学技术大学 合肥 230026
  • 收稿日期:2013-03-14 出版日期:2013-08-14 发布日期:2013-04-17
  • 通讯作者: 龚流柱, E-mail: gonglz@ustc.edu.cn; Tel.: 0086-0551-63600671; Fax: 0086-0551-63606266 E-mail:gonglz@ustc.edu.cn
  • 基金资助:

    项目受中央高校基本科研业务费专项资金(No. WK2340000043)资助.

Asymmetric Relay Catalysis Reaction Consisting of Metal Complex and Chiral Phosphoric Acids

Wu Xiang, Li Mingli, Gong Liuzhu   

  1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry,University of Science and Technology of China, Hefei 230026
  • Received:2013-03-14 Online:2013-08-14 Published:2013-04-17
  • Supported by:

    Project supported by the Fundamental Research Funds for the Central Universities (No. WK2340000043).

Metal complex and organo combined catalysis is a new and exciting research area and has attracted close attention. Relay catalysis (or sequential catalysis), in which both the organocatalyst and the metal catalyst perform two distinct catalytic cycles for the consecutive reactions, enables the assembling readily available starting materials into structurally complex molecules. Besides, relay catalysis can also accomplish unprecedented reactions, which are not accessible through the use of either of the catalytic systems alone. More essentially, it avoids the purification of unstable intermediate and improves process economy and atom economy. Chiral phosphoric acids become the hottest kind of organocatalysts in recent decades. Chiral phosphoric acid has been applied to asymmetric transfer hydrogenation of imines, enantioselective Friedel-Crafts reaction, Mannich reaction, hydrophosphonylation reaction, Strecker reaction, aza-Diels-Alder reaction, alkylation of diazoester reaction and so on. Chiral phosphoric acid can act as both proton donor and proton acceptor simultaneously, and the system of which combining with metal has attracted intensive study. Transition metal catalysis was dominated in catalytic organic synthesis. Owing to the explosive development of organocatalysis in recent years, the combination of transition metal catalysts and organocatalysts has displayed as a new and powerful strategy for developing new and useful reactions, and has attracted increasing attention. In this review, we summarize recent progress in the field of metal complex/phosphoric acids relay catalysis. And in our opinion, the study of new catalysis systems will continue to be an exciting research area, the inquiry of the applications in the total synthesis of natural products is worthy of further investigation and the exploration of appropriate catalysis systems applied in industrial production represents the future research direction.

Key words: metal complex, chiral phosphoric acids, asymmetric, relay catalysis