Acta Chim. Sinica ›› 2016, Vol. 74 ›› Issue (9): 744-751.DOI: 10.6023/A16060302 Previous Articles     Next Articles

Article

新型温度/pH敏感性ABA型三嵌段共聚物的合成、胶束化及凝胶化行为研究

韩雅楠, 刘守信, 毛虹光, 田蕾, 宁文燕   

  1. 应用表面与胶体化学教育部重点实验室 陕西师范大学化学化工学院 西安 710062
  • 收稿日期:2016-06-28 出版日期:2016-09-10 发布日期:2016-08-10
  • 通讯作者: 刘守信 E-mail:liushx@snnu.edu.cn
  • 基金资助:

    项目受国家自然科学基金(20973106),中央高校基本科研业务费专项资金(GK201301004),长江学者和创新团队发展计划(IRT_14R33)资助.

Studies on the Synthesis, Micellization and Gelation of Novel Temperature- and pH-Sensitive ABA Triblock Copolymers

Han Yanan, Liu Shouxin, Mao Hongguang, Tian Lei, Ning Wenyan   

  1. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China
  • Received:2016-06-28 Online:2016-09-10 Published:2016-08-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (20973106), the Fundamental Research Funds for the Central Universities of China (GK201301004), and the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R33).

Novel ABA triblock copolymers P(DEAEMA-co-MEO2MA-co-HMAM)-b-PEG-b-P(DEAEMA-co-MEO2MA-co-HMAM) with different polymerization degrees which were more hydrophilic were synthesized by ATRP (atom transfer radical polymerization). The composition and structure of the copolymer were characterized by 1H NMR, FT-IR, and gel permeation chromatograph (GPC). The temperature- and pH-sensitivity and micellization of the ABA triblock copolymer have been studied using transmittance, surface tension, fluorescence spectra, dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. The effects of temperature and pH on the gelation of the copolymer were studied through the gel state and the process of sol-gel transitions of copolymer induced by temperature at different pHs. The drug release of a drug-loaded gel which informed by the copolymer was tested respectively at different temperatures and pHs in buffer solutions. It was found that the copolymer had a good temperature- and pH-sensitivity, and the copolymer chains can form stable core-shell structure micelles through temperature and pH inducing. The different strength of gel can be induced by pH. In addition, the drug release of the drug-loaded gel was increased with the decrease of temperature and pH values.

Key words: temperature- and pH-sensitivity, micellization, gelation, drug release