Acta Chim. Sinica ›› 2015, Vol. 73 ›› Issue (1): 47-52.DOI: 10.6023/A14100710 Previous Articles     Next Articles



刘水莲a, 周洋a, 陈福花b, 朱寿进a, 宿烽a, 李速明c   

  1. a 青岛科技大学 高性能聚合物研究院 青岛 266042;
    b 青岛中化新材料实验室 青岛 266042;
    c 蒙彼利埃二大 欧洲薄膜研究院 法国 蒙彼利埃 34095
  • 投稿日期:2014-10-14 发布日期:2014-12-09
  • 通讯作者: 宿烽, 李速明;
  • 基金资助:

    项目受国家自然科学基金(Nos. 50873030, 51073041)资助.

Rheological Properties, Drug Release Behavior and Cytocompatibility of Novel Hydrogels Prepared from Carboxymethyl Chitosan

Liu Shuiliana, Zhou Yanga, Chen Fuhuab, Zhu Shoujina, Su Fenga, Li Sumingc   

  1. a Institute of High Performance Polymer, Qingdao University of Science and Technology, Qingdao 266042;
    b Qingdao Sinochem New Materials Laboratory, Qingdao 266042;
    c Institut Europeen des Membranes, UMR CNRS 5635, Universite Montpellier II, Montpellier 34095, France
  • Received:2014-10-14 Published:2014-12-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 50873030, 51073041).

Hydrogels were prepared by crosslinking carboxymethyl chitosan (CMCS) using 1-ethyl-3-(3-dimethylamino- propyl)-1-carbodiimide/N-hydroxysuccinimide (EDC/NHS) as catalyst under mild conditions. The resulting hydrogels present different crosslinking density, depending on the amount of EDC/NHS. Rheological studies show that hydrogels with high crosslinking density present higher storage modulus than those with low crosslinking density. A model drug, thymopentin (TP-5) is loaded in CMCS hydrogels. Parabolic release profiles are obtained in all cases. High crosslinking density hydrogels present slower release rate as compared to low crosslinking density ones because the former exhibits more compact structure. Preliminary studies were performed to evaluate the cytotoxicity of CMCS hydrogels by using MTT assay. Both cell morphology and RGR results show that the CMCS hydrogels present very low toxicity. Therefore, CMCS hydrogels are promising for applications in the fields of tissue engineering and controlled drug delivery.

Key words: carboxymethyl chitosan, hydrogel, rheological properties, drug release, cytocompatibility