The relationship between genetic codons and amino acids has attracted much attentions since the discovery of first genetic codon. Although we have known that relationship of codons and amino acids clearly, even some rare amino acids also have their codons in certain creatures, we do not know the real principle that how a codon detertmine an amino acid. In fact, the codon is a little far from amino acid in a tRNA. With many efforts, we have not detect the secret of codon. Before we used nuclear magnetic resonance (NMR) and high resolution mass spectrum (HRMS) to detect the product of reaction of amino acids, nucleosides and sodium trimetaphosphate to find out the relationship between amino acid and nucleoside. But the productivity was too low to determine. Electronic tongue is a machine used to determine the whole variant of a solution, especially in food industry, it could determine very subtle variant. So we use it to determine the whole variant of our system. In this work, we reported the reactions between amino acids, nucleosides and sodium trimetaphosphate. Each ingredient was 0.0008 mol/L and pH was adjusted to 11 by NaOH, then reacted at 50 ℃for 48 h. The reacted mixture was cooled down to room temperature and detected by electronic tongue. Also, the samples that were freshly prepared were detected by electronic tongue to be original data. The overall changes of the reaction mixtures were characterized by the average of Euclidean Distance. The results show that the nucleosides in middle of codon or anticodon displayed the greatest effect on the reactions. The results also indicate that there are significant interrelations between amino acids and nucleosides, which was also proved by the difference between the results of leucine and isoleucine. In summary, the results may open a new avenue to the study of the relationship between genetic codens and amino acids and origin of life.

Key words: codon, amino acid, electronic tongue, nucleoside, origin of life