Seven chiral phase-transfer catalysts, e.g., N-benzylquininium chloride and N-benzylcinchoninium chloride have been prepared and applied to the asym. alkylation of a-isopropylbenzyl cyanide and a-isopropyl-p-chlorobenzyl cyanide. The result showed that short reaction time, low temperature, high catalyst concentration and non-polar solvent would improve the optical yield. The influence of structure on the catalyst on the asym. reaction was preliminarily studied. The optical purity of the products was evaluated by gas chromatog. with a chiral column.

Key words: CHLORIDE, CHEMICAL REACTION, ISOPROPYL GROUP, ISOPROPYL GROUP, ALKYLATION, BROMOHYDROCARBON, BENZYL GROUP, PHASE TRANSFER CATALYST, CHLOROBENZENE P, ACETONITRILE P