Isolation and structures of schisanlactone E and changnanic acid

Abstract

Two new triterpenoid compounds, schisanlactone E (I) and changnanic acid (II), along with three known compounds, schisanlactone B (III), meso-dihydroguaiaretic acid and b-sitosterol, were isolated from the root bark of Kadsura longipedunculata Finet. et Gagnep. indigenous to the Lin-An district in Zhejiang province of China. Their structures were elucidated by spectroscopic studies. In an anticancer screening I and II show significant inhibition of leukemia p-388 cells in vitro (IC50 1 mg/mL and 10 mg/mL resp.).

Key words: CARBOXYLIC ACID, TERPENE, HYDROXY GROUP, TRITERPENE, ISOPROPENYL GROUP, UNSATURATED ESTERS, ANTITUMOR DRUGS, SCHISANDRA CHINENSIS

CLC Number:

O629

Cite this article

WAI JIASEN;HUANG MEIFEN. Isolation and structures of schisanlactone E and changnanic acid[J]. Acta Chimica Sinica, 1991, 49(5): 502-506.

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