Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (6): 641-643. Previous Articles    

Original Articles

手性螺-环丙烷双内酯化合物的合成与结构

黄慧;陈庆华   

  1. 北京师范大学化学系.北京(100875)
  • 出版日期:1999-06-15 发布日期:1999-06-15

Synthesis and structure of the chiral spiro-cyclopropane derivatives

Huang Hui;Chen Qinghua   

  1. Beijing Normal Univ., Dept of Chem..Beijing(100875)
  • Online:1999-06-15 Published:1999-06-15

Tandem asymmetric reactions of 1 with nucleophilic alcohols afforded optically pure spirocyclopropane derivatives with four stereogenic centers 4a-4e in 64%-88% yields with d.e.≥98%. The optically pure compounds 4a-4e were identified on the basis of their analytical data, such as [α]~D^2^0, UV, IR, ^1H NMR, ^1^3C NMR, MS and elemental analysis. The absolute configuration of the chiral spirocyclopropane compound (4a) was established by X-ray crystallography.

Key words: CYCLOPROPANE P, LACTONES, SPIRO COMPOUNDS, CRYSTAL STRUCTURE, MICHAEL ADDITION REACTION, NUCLEOPHILIC REACTION, SUBSTITUTION REACTION

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