Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (19): 2138-2140. Previous Articles     Next Articles

Original Articles

外消旋木榄醇甲的简捷合成

吴建忠a,b 甄志彬b 张奕华a 伍贻康*,b

  

  1. (a中国药科大学新药研究中心 南京 210009)
    (b中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032)

  • 收稿日期:2008-05-08 修回日期:2008-07-21 出版日期:2008-10-14 发布日期:2008-10-14
  • 通讯作者: 伍贻康

An Expeditious Synthesis of (±)-Bruguierol A

WU, Jian-Zhong a,b ZHEN, Zhi-Bin b ZHANG, Yi-Hua a WU, Yi-Kang *,b   

  1. (a Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009)
    (b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry,
    Chinese Academy of Sciences, Shanghai 200032)
  • Received:2008-05-08 Revised:2008-07-21 Online:2008-10-14 Published:2008-10-14
  • Contact: WU, Yi-Kang

A highly efficient synthesis of racemic bruguierol A (a natural product) is presented. The key bridged cyclic framework was constructed using an intromolecular Friedel-Crafts alkylation with a ketal as the alkylating agent developed in our group several years ago.

Key words: Fredel-Crafts reaction, bridged ring, natural product, total synthesis, ketal