Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (23): 2653-2657. Previous Articles    

Reports

PPEGMEA-g-PMAA全亲水接枝共聚物包埋甲氨喋呤体外控释的研究

黄晓炜a 顾丽娜b 陆国林b 黄 啸*,a 张亚琴b 黄晓宇*,b

  

  1. (a复旦大学附属肿瘤医院妇科 复旦大学上海医学院肿瘤学系 上海 200032)
    (b中国科学院上海有机化学研究所 上海 200032)

  • 投稿日期:2008-07-18 修回日期:2008-08-28 发布日期:2008-12-14
  • 通讯作者: 黄晓宇

Studies on Controlled Drug Release in vitro of Methotrexate Loaded by PPEGMEA-g-PMAA Double Hydrophilic Graft Copolymer

HUANG, Xiao-Wei a GU, Li-Na b LU, Guo-Lin b HUANG, Xiao *,a
ZHANG, Ya-Qin b HUANG, Xiao-Yu *,b
  

  1. (a Department of Gynecology, Cancer Hospital, Fudan University, Department of Oncology, Shanghai Medical College,
    Fudan University, Shanghai 200032)
    (b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2008-07-18 Revised:2008-08-28 Published:2008-12-14
  • Contact: HUANG, Xiao-Yu

Methotrexate-loaded polymeric micelles using PPEGMEA-g-PMAA double hydrophilic graft copolymer as carrier were prepared by physical entrapping and chemical bonding. The effects of pH and preparation method on drug loading content (DLC), drug loading efficiency (DLE) and drug release were studied. Drug release of both micelles can be controlled by pH.

Key words: double hydrophilic graft copolymer, drug release, methotrexate