The synthesis of 2-(4-substituted phenyl-2-oxo-3-amido-1-azetidinyl)-2-phenylacetic acids

Acta Chimica Sinica ›› 1988, Vol. 46 ›› Issue (7): 719-723. Previous Articles Next Articles

Original Articles

2-[4-取代苯基-2-氧-3-酰氨基-1-吖丁啶基]-2-苯基乙酸类化合物的合成

童晓禾;李正化

华西医科大学药学院

发布日期:1988-07-15

The synthesis of 2-(4-substituted phenyl-2-oxo-3-amido-1-azetidinyl)-2-phenylacetic acids

TONG XIAOHE;LI ZHENGHUA

Published:1988-07-15

Abstract

Title compounds I (R = PhOCH2, PhCH2; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 3-BrC6H4, 4-MeO2SC6H4, 4-MeC6H4, 4-MeOC6H4, 4,2-BrClC6H3) were prepared starting from D-phenylglycine. Twenty title compounds have been synthesized and nine of them showed inhibitory activity against b-lactamase.

Key words: SODIUM COMPOUNDS, LACTAMASE, AMIDES, AZIDE, BENZENE P, LACTAM, STYRENE P, GLYCINE, INHIBITOR, AZETIDINE P

CLC Number:

O621

Cite this article

TONG XIAOHE;LI ZHENGHUA. The synthesis of 2-(4-substituted phenyl-2-oxo-3-amido-1-azetidinyl)-2-phenylacetic acids[J]. Acta Chimica Sinica, 1988, 46(7): 719-723.

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2-[4-取代苯基-2-氧-3-酰氨基-1-吖丁啶基]-2-苯基乙酸类化合物的合成

The synthesis of 2-(4-substituted phenyl-2-oxo-3-amido-1-azetidinyl)-2-phenylacetic acids

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