Supported bilayer lipid membrane (s-BLM) was served as a biomembrane model. The interaction between s-BLM and hydroxyl free radical (•OH) produced by Fenton system was investigated by means of cyclic voltammetry. The results show that •OH can induce pore or defect on s-BLM through chemical interaction with lecithin. The interaction between them depends on time, concentration of FeSO₄ and H₂O₂, moreover, it is not reversible. Through redox reaction with •OH, the antioxidants including vitamin C, glutathione and L-cysteine which contain reducive radicals, can suppress the interaction between •OH and BLM. Therefore, they can decrease the destructive degree of the structrue of s-BLM.

Key words: supported bilayer lipid membrane, cyclic voltammetry, hydroxyl free radical, antioxidant