Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of  Loaded Methotrexate

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (12): 1363-1369. Previous Articles Next Articles

Original Articles

PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其包埋甲氨喋呤体外控释的研究

黄晓炜a 顾丽娜b 陆国林b 黄啸*,a 张亚琴b 黄晓宇*,b

(a复旦大学附属肿瘤医院妇科复旦大学上海医学院肿瘤学系上海 200032)
(b中国科学院上海有机化学研究所上海 200032)

投稿日期:2009-02-16 修回日期:2009-03-17 发布日期:2009-06-28
通讯作者: 黄晓宇

Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of Loaded Methotrexate

Huang, Xiaowei ^a Gu, Lina ^b Lu, Guolin ^b Huang, Xiao ^*,aZhang, Yaqin ^b Huang, Xiaoyu ^*,b

(a Department of Gynecology, Cancer Hospital, Fudan University; Department of Oncology, Shanghai Medical College,
Fudan University, Shanghai 200032)
(b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

Received:2009-02-16 Revised:2009-03-17 Published:2009-06-28
Contact: Huang, Xiaoyu

Abstract

A well-defined poly[poly(ethylene glycol) methyl ether acrylate]-g-poly[(N,N’-diethylamino)-
ethyl methacrylate] (PPEGMEA-g-PDEAEMA) graft copolymer was synthesized by the combination of atom radical transfer polymerization (ATRP) and the grafting-from strategy using poly(ethylene glycol) methyl ether acrylate (PEGMEA) as starting material. PPEGMEA-g-PDEAEMA-based micelles formed by electrostatic complexes were employed to load methotrexate (MTX) with a high drug loading efficiency of 98.7% and the drug release in vitro was well controlled.

Key words: double hydrophilic graft copolymer, micelle, drug release

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PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其包埋甲氨喋呤体外控释的研究

Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of Loaded Methotrexate

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PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其 包埋甲氨喋呤体外控释的研究

Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of Loaded Methotrexate

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Knowledge

Cited

Abstract

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Related Articles 15

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PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其包埋甲氨喋呤体外控释的研究