The relationship of conformation ,stability and biological activity of trichosanthin in aqueous solution

Acta Chimica Sinica ›› 1992, Vol. 50 ›› Issue (9): 914-917. Previous Articles Next Articles

Original Articles

天花粉蛋白溶液构象与稳定性及生物活性的关系

田庚元;张孝先;沈春镒

中国科学院上海有机化学研究所;中国科学院上海药物研究所

发布日期:1992-09-15

The relationship of conformation ,stability and biological activity of trichosanthin in aqueous solution

TIAN GENYUANG;ZHANG XIAOXIAN;SHEN CHUNYI

Published:1992-09-15

Abstract

The conformation of trichosanthin in aqueous solution under different pH, temperature and keeping time has been investigated by CD. The stable external surroundings of trichosanthin solution, for example, pH, temperature and keeping time, has been explained. The relationship between the conformation of trichosanthin solution and the antireproductive activity has been also studied. The result showed that the a-helix in the solution has the pos. relation with antireproductive activity. Antireproductive activity increases along with the a-helix in the solution, and it disappears while a-helix in the solution decreases to less than 15%.-

Key words: STABILITY, BIOLOGICAL ACTIVITY, CIRCULAR DICHROISM, RICHOSATHIN PROTEIN

CLC Number:

O629

Cite this article

TIAN GENYUANG;ZHANG XIAOXIAN;SHEN CHUNYI. The relationship of conformation ,stability and biological activity of trichosanthin in aqueous solution[J]. Acta Chimica Sinica, 1992, 50(9): 914-917.

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天花粉蛋白溶液构象与稳定性及生物活性的关系

The relationship of conformation ,stability and biological activity of trichosanthin in aqueous solution

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