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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (21): 2523-2526. Previous Articles     Next Articles

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铜(Ⅰ)催化亚铁氰化钾对含氮杂环溴化物的氰基化反应

蔡良珍,刘斌,董于虎,杜广延,陶晓春   

  1. (华东理工大学化学与分子工程学院 上海 200237)
  • 投稿日期:2009-05-08 修回日期:2009-07-01 发布日期:2010-01-05
  • 通讯作者: 陶晓春 E-mail:xctao@ecust.edu.cn

Copper(I) Iodide Catalyzed Cyanation of N-Heteroaryl Bromides Using Potassium Hexacyanoferrate(II)

Cai, Liangzhen      Liu, Bin       Dong, Yuhu       Du, Guangyan      Tao, Xiaochun*   

  1. (School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237)
  • Received:2009-05-08 Revised:2009-07-01 Published:2010-01-05

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An efficient and user-friendly synthesis for a series of N-heteroaryl nitriles is described. This process is based on the CuI catalyzed cyanation of N-heteroaryl bromides with K4[Fe(CN)6] in the presence of N-isopropylimidazole and N,N-dimethylethylenediamine. The results show that the reaction has good to high yields.

Key words: potassium hexacyanoferrate(II), cyanation, N-isopropylimidazole, N,N-dimethylethylene- diamine, N-heteroaryl nitrile