Studies on the acylthiosemicarbazides and related heterocyclic derivatives I: Synthesis of 1-cyanoacetyl-4-aryl-thiosemicarbazides and related heterocyclic derivatives

Acta Chimica Sinica ›› 1987, Vol. 45 ›› Issue (4): 403-407. Previous Articles Next Articles

Original Articles

酰氨基硫脲及有关的杂环衍生物的研究 I:1-氰乙酰基-4-芳基氨基硫脲及有关的杂环衍生物的合成

张自义;杨虎;高东哲

兰州大学化学系;北京结核病院

发布日期:1987-04-15

Studies on the acylthiosemicarbazides and related heterocyclic derivatives I: Synthesis of 1-cyanoacetyl-4-aryl-thiosemicarbazides and related heterocyclic derivatives

ZHANG ZIYI;YANG HU;GAO DONGZHE

Published:1987-04-15

Abstract

Refluxing NCCH2CONHNH2 with RNCS (R = Ph, 4-MeOC6H4, 4-ClC6H4, 3-BrC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl, 4-BrC6H4, 3,4-Me2C6H3) in EtOH gave NCCH2CONHNHC(S)NHR (I). Cyclization of I (R = Ph, 4-MeOC6H4, 4-MeC6H4, 3,4-Me2C6H2) with aqueous K2CO3 gave triazolinethiones II, whereas cyclization of I (R = Ph) with concentrated H2SO4 gave thiadiazoles III (R1 = NCCH2, H2NCOCH2).

Key words: THIOKETONE, NITROGEN HETEROCYCLICS, PLANT GROWTH REGULATORS, THIADIAZOLE P, PYRRODIAZOLE P, THIOCYANIC ACID ESTER, CYANOACETIC ACID P, THIOSEMICARBAZIDE P, HYDRAZIDE P

CLC Number:

O621
TQ45

Cite this article

ZHANG ZIYI;YANG HU;GAO DONGZHE. Studies on the acylthiosemicarbazides and related heterocyclic derivatives I: Synthesis of 1-cyanoacetyl-4-aryl-thiosemicarbazides and related heterocyclic derivatives[J]. Acta Chimica Sinica, 1987, 45(4): 403-407.

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酰氨基硫脲及有关的杂环衍生物的研究 I:1-氰乙酰基-4-芳基氨基硫脲及有关的杂环衍生物的合成

Studies on the acylthiosemicarbazides and related heterocyclic derivatives I: Synthesis of 1-cyanoacetyl-4-aryl-thiosemicarbazides and related heterocyclic derivatives

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