The hydrolysis of adenosine-5'-monophosphate (5'-AMP) and guanosine-5'-monophosphate (5'-GMP) by lanthanides was investigated. 5'-AMP and 5'-GMP was efficiently hydrolyzed by cerium(Ⅲ) chloride under air at pH 9 and 37℃, and other lanthanides(Ⅲ) showed less efficiency at the same condition. The hydrolysis rate of 5'-AMP by cerium was greater than that of 5'-GMP. UV spectra showed that Ce(Ⅲ) was oxidized to Ce(Ⅳ) in the reaction mixture. The active species for the hydrolysis of 5'-AMP and 5'-GMP was ascribed to the Ce(Ⅳ) hydroxide cluster in the reaction mixture.

Key words: GUANINE, FRACTURE, OLIGONUCLEOTIDE, RARE ELEMENT, ADENINE, HYDROLYSIS