The asymmetric miorobiologioal rednotion of the prochiral 13-ethyl-3-methoxy-8,14-seco-Δ^{1,3,5(10)9(11)}-estratetraen-14，17-dione (Ⅲ) with Saccharomyces cerevisirae (2.346) was suoressful to afford an optical active key intermediate IV in an excellent yield.The D-norgestrel (Ⅰ) and D-13-ethyl norgestrienone (Ⅱ) were synthesized from this optically active intermediate (N) via 8-step and 11-step routes, the total yields amounted to 36.6 and 10%，respectively.