Acta Chim. Sinica ›› 2017, Vol. 75 ›› Issue (1): 22-33.DOI: 10.6023/A16080418 Previous Articles     Next Articles

Special Issue: 有机光化学



王德红a,b, 张龙a,b, 罗三中a,b   

  1. a 中国科学院化学研究所 分子识别与功能院重点实验室 北京 100190;
    b 中国科学院大学 北京 100049
  • 投稿日期:2016-08-16 修回日期:2016-09-13 发布日期:2016-09-18
  • 通讯作者: 罗三中,;Tel.:0086-010-62554446
  • 作者简介:王德红:中国科学院化学研究所2013级在读硕博生,本科就读于东北师范大学.现在主要研究光催化和伯胺催化的不对称转化反应;张龙:中国科学院化学研究所分子识别与功能重点实验室副研究员.主要从事不对称光催化、仿生伯胺催化及其理论计算研究;罗三中:中国科学院化学研究所研究员、博士生导师,分子识别与功能重点实验室副主任.主要从事仿生小分子催化合成和物理有机研究.
  • 基金资助:


Photo-induced Catalytic Asymmetric Free Radical Reactions

Wang Dehonga,b, Zhang Longa,b, Luo Sanzhonga,b   

  1. a Key Laboratory of Molecular Recognition and Functions, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190;
    b University of Chinese Academy of Sciences, Beijing 100049
  • Received:2016-08-16 Revised:2016-09-13 Published:2016-09-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21572232, 21390400).

Enantioselective control of free radical reactions has eluded organic chemists for decades. Echoed with the renaissance of photo-induced processes, or so called photocatalysis or photoredox catalysis in organic synthesis, photo-induced organic radical chemistry has regained its prominence in developing catalytic asymmetric radical reaction. The generally mild conditions inherited with photochemistry, particularly visible light photo-processes, have allowed for controllable generation of free radicals as well as the subsequent bond formations. The past five years have witnessed dramatic advances in exploring photo-induced catalytic asymmetric free radical reactions, and enormous potentials along this line are envisaged. This perspective gives a brief summary on the important advances in this field. Accordingly, the major advances are classified based on different radical species including α-amino/oxyl radicals, radicals generated from enones and its analogues, benzyl radicals, α-carbonyl radicals, polyhalogenated alkyl radicals and nitrogen radicals. Brief discussion of mechanism is presented whenever relevant.

Key words: photoredox catalysis, free radical reaction, asymmetric catalysis, synergistic catalysis