Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 164-168.DOI: 10.6023/cjoc201208022 Previous Articles     Next Articles



陈华a, 周利凯a, 李帅a, 姚玉超a, 谷云景a, 李春晓b, 李娜b, 孟明b, 李小六a   

  1. a 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002;
    b 河北大学医学部 保定 071002
  • 收稿日期:2012-08-21 修回日期:2012-09-27 发布日期:2012-10-09
  • 通讯作者: 孟明, 李小六;
  • 基金资助:

    国家自然科学基金(Nos. 20902016, 20972039);河北省自然科学基金石药集团医药联合基金(No. B2011201169)和河北省教育厅自然科学基金(No. ZH2011110)资助项目.

Synthesis of 3,4-Biphenyl Coumarin Derivatives and Their Promoting Effects on the Killing Activity of Natural Killing Cell

Chen Huaa, Zhou Likaia, Li Shuaia, Yao Yuchaoa, Gu Yunjinga, Li Chunxiaob, Li Nab, Meng Mingb, Li Xiaoliua   

  1. a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b Medical School, Hebei University, Baoding 071002
  • Received:2012-08-21 Revised:2012-09-27 Published:2012-10-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20902016, 20972039), the Medicinal Joint Funds of the Natural Science Foundation of Hebei Province and Shijiazhuang Pharmaceutical Group Foundation (No. B2011201169) and the Natural Science Foundations of Education Department of Hebei Province (No. ZH2011110).

A series of novel 3,4-biphenyl coumarin derivatives containing an amino side chain 1a1e were synthesized using salicylic acid as starting material via Fridel-Crafts acylation, then the microwave-assisted Perkin reaction and double SN2 substitution reactions. The preliminary biological evaluation showed that compounds 1a1e had significant promoting effects on the killing activity of natural killer cell, and hold potential as immunomodulating agents.

Key words: coumarin, Perkin reaction, natural killer cell, immunomodulating activity