Synthesis and Anticancer Activity of Novel Coumarin Derivatives

doi:10.6023/cjoc201911028

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1598-1607.DOI: 10.6023/cjoc201911028 Previous Articles Next Articles

新型香豆素类衍生物的合成及抗肿瘤活性研究

时蕾^a, 李子秋^a, 崔鑫鑫^b, 朱挺^b, 庞晓静^b, 李龙辉^a, 罗德福^a, 刘方芳^b, 赵冰玉^b, 龙跃^a, 张赛扬^c

a 郑州大学化学学院郑州 450001;
b 郑州大学药学院郑州 450001;
c 郑州大学基础医学院郑州 450001

收稿日期:2019-11-23 修回日期:2020-01-15 发布日期:2020-04-09
通讯作者: 龙跃, 张赛扬 E-mail:longyue@zzu.edu.cn;saiyangz@zzu.edu.cn
基金资助:
国家自然科学基金（Nos.81703541，81673322）和中国博士后科学基金（No.2018M632812）资助项目.

Synthesis and Anticancer Activity of Novel Coumarin Derivatives

Shi Lei^a, Li Ziqiu^a, Cui Xinxin^b, Zhu Ting^b, Pang Xiaojing^b, Li Longhui^a, Luo Defu^a, Liu Fangfang^b, Zhao Bingyu^b, Long Yue^a, Zhang Saiyang^c

a College of Chemistry, Zhengzhou University, Zhengzhou 450001;
b School of Pharmaceutical Sciences, Zhengzhou 450001;
c School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001

Received:2019-11-23 Revised:2020-01-15 Published:2020-04-09
Supported by:
Project supported by the National Natural Sciences Foundations of China (Nos. 81703541, 81673322) and the China Postdoctoral Science Foundation (No. 2018M632812).

1. 201598S.pdf(9591KB)

Abstract

Nineteen novel 3,4,5-trimethoxyphenyl coumarin derivatives have been synthesized and evaluated for antitumor activity against three human cancer cell lines (EC-109, PC-3 and MGC-803). These chemical structures were well characterized by NMR and HRMS spectroscopic methods. N-Benzyl-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3,4,5-trimethoxy-phenyl)acetamide) (4a) and N-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3,4,5-trimethoxyphenyl)acetamide) (4n) had better inhibitory activity against three kinds of tumor cells than 5-fluorouracil. Compound 4n showed the most potent antitumor activity against PC-3 cells with an IC₅₀ value of 4.18 μmol/L.

Key words: coumarin, anticancer, synthesis

Cite this article

Shi Lei, Li Ziqiu, Cui Xinxin, Zhu Ting, Pang Xiaojing, Li Longhui, Luo Defu, Liu Fangfang, Zhao Bingyu, Long Yue, Zhang Saiyang. Synthesis and Anticancer Activity of Novel Coumarin Derivatives[J]. Chinese Journal of Organic Chemistry, 2020, 40(6): 1598-1607.

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新型香豆素类衍生物的合成及抗肿瘤活性研究

Synthesis and Anticancer Activity of Novel Coumarin Derivatives

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