Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 143-147.DOI: 10.6023/cjoc201208029 Previous Articles     Next Articles



徐海珍a, 朱有全b, 谢丽芬b, 王晓芳b   

  1. a 天津师范大学化学学院 天津 300387;
    b 南开大学元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2012-08-28 修回日期:2012-09-22 发布日期:2012-09-26
  • 通讯作者: 徐海珍, 朱有全;
  • 基金资助:

    国家973计划(No. 2010CB126103);国家自然科学基金(Nos. 20772066, 21072108)和“十二五”科技支撑计划(No. 2011BAE06B05-3)资助项目.

Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives

Xu Haizhena, Zhu Youquanb, Xie Lifenb, Wang Xiaofangb   

  1. a College of Chemistry, Tianjin Normal University, Tianjin 300387;
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
  • Received:2012-08-28 Revised:2012-09-22 Published:2012-09-26
  • Supported by:

    Project support by the National Basic Research Program of China (973 Program) (No. 2010CB126103), the National Natural Science Foundation of China (Nos. 20772066, 21072108) and the National Key Technologies R&D Program (No. 2011BAE06B05-3).

To find new lead compounds with muti-bioactivities, a series of novel 2-aroyl-5-alkylcyclopentanone derivatives containing 2-bezoylenthenol were designed on the base of various commercial products. The target compounds were synthesized from diethyl adipate in 6 steps. Their structures were confirmed by IR, 1H NMR spectra, X-ray and elemental analysis or HRMS. The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Brassica campestris, and the herbicidal activities were more than 60% at 100 μg/mL.

Key words: 4-hydroxyphenylpyruvate dioxygenase, 2-bezoylenthenol, cyclopropanone, herbicidal activity