Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 232-236.DOI: 10.6023/cjoc201607031 Previous Articles     Next Articles



翟志文, 汪乔, 沈钟华, 谭成侠, 翁建全, 刘幸海   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2016-07-20 修回日期:2016-08-25 发布日期:2016-09-01
  • 通讯作者: 刘幸海
  • 基金资助:

    浙江省自然科学基金(No. LY16C14007)和浙江省科技厅科研院所专项(No. 2015F50030)资助项目.

Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety

Zhai Zhiwen, Wang Qiao, Shen Zhonghua, Tan Chengxia, Weng Jianquan, Liu Xinghai   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2016-07-20 Revised:2016-08-25 Published:2016-09-01
  • Supported by:

    Project supported by the Zhejiang Provincial Science Foundation of China(No. LY16C14007) and the Research Institute Special Program of Department of Science and Technology of Zhejiang Province(No. 2015F50030).

A series of novel 1,2,4-triazole derivatives were synthesized from ethyl trifluoroacetoacetate,triethyl orthoformate,methylhydrazine,phenyl isothiocyanate by multi-step reactions.Their structures were characterized by 1H NMR,13C NMR,HRMS and X-ray diffraction.The target compounds were evaluated for their fungicidal activity and herbicidal activitiy.The results indicated that some of the title compounds displayed certain fungicidal activities against Colletotrichum orbiculare and herbicidal activity against dicotyledons.

Key words: pyrazole, 1,2,4-triazole, synthesis, fungicidal activity, herbicidal activity