Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (05): 1074-1079.DOI: 10.6023/cjoc201210020 Previous Articles     Next Articles



陈玉a, 柏舜a, 艾勇b, 范华b, 杨光忠b   

  1. a 中南民族大学化学与材料科学学院 武汉 430074;
    b 中南民族大学药学院 武汉 430074
  • 收稿日期:2012-10-13 修回日期:2012-12-16 发布日期:2013-01-04
  • 通讯作者: 杨光忠,
  • 基金资助:

    国家科技支撑计划(No. 2012BAI27B06)资助项目.

Synthesis and Antimicrobial Evaluation of Novel Pyrimidoquinolines

Chen Yua, Bai Shuna, Ai Yongb, Fan Huab, Yang Guangzhongb   

  1. a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074;
    b College of Pharmacy, South-Central University for Nationalities, Wuhan 430074
  • Received:2012-10-13 Revised:2012-12-16 Published:2013-01-04
  • Supported by:

    Project supported by the National Key Technology R&D Program in the 12th Five Year Plan of China (No. 2012BAI27B06).

A facile and efficient approach was adopted for the synthesis of a series of novel pyrimido[5,4- c]quinolin-4(3H)-one derivatives. All the synthesized compounds were characterized using spectroscopic data (IR, 1H NMR, and mass spectrometry) and evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) as well as fungi (Canibia albican) by broth microdilution method. The antimicrobial screening revealed that the tested compounds showed slightly to moderate antibacterial and antifungal activities.

Key words: pyrimidoquinoline derivative, antimicrobial evaluation, azo-Wittig reaction