Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (11): 2291-2297.DOI: 10.6023/cjoc201306023 Previous Articles     Next Articles

Reviews

脱卤反应研究进展

薛福玲a, 熊金锋a, 莫广珍a, 彭湃a, 陈任宏b, 汪朝阳a   

  1. a 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006;
    b 广东食品药品职业学院 广州 510520
  • 收稿日期:2013-06-16 修回日期:2013-07-08 出版日期:2013-11-25 发布日期:2013-07-11
  • 通讯作者: 汪朝阳 E-mail:wangzy@scnu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 20772035)、广东省高等学校人才引进专项资金(No. 粤财教[2011]431号)、广东省自然科学基金(No. S2011010001556)资助项目.

Research Progress on Dehalogenation Reaction

Xue Fulinga, Xiong Jinfenga, Mo Guangzhena, Peng Paia, Chen Renhongb, Wang Zhaoyanga   

  1. a Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006;
    b Guangdong Food and Drug Vocational College, Guangzhou 510520
  • Received:2013-06-16 Revised:2013-07-08 Online:2013-11-25 Published:2013-07-11
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20772035), the 3rd Talents Special Funds of Guangdong Higher Education (No. Guangdong-Finance-Education [2011]431) and the Natural Science Foundation of Guangdong Province (Nos. 5300082, S2011010001556).

Dehalogenation reaction has important applications in many fields, such as environmental protection, biochemistry and organic synthesis. Especially, more and more attention has been paid to the formation of C—H bond via the dehalogenation reaction in organic synthesis. Based on different reaction substrates, the recent research progresses on the dehalogenation reaction of Csp3-X and Csp2-X substrates, especially the aryl halides (including halogenated aromatic heterocycles), halogen ketones, halogenated lactones, are reviewed. It is pointed that to improve the selectivity and practicality of dehalogenation reactions is the key for their further extensive uses in organic synthesis. At the same time, the dehalogenation via photochemical reaction as a novel green chemistry route is also worthy of further study in the future.

Key words: dehalogenation reaction, palladium-catalyzed, reduction reaction, hydrogen source, photochemical reaction