Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (11): 2298-2309.DOI: 10.6023/cjoc201305044 Previous Articles     Next Articles

Reviews

金属催化芳基硼酸与酮不对称1,2-加成反应研究进展

罗人仕, 廖建华, 张剑   

  1. 赣南医学院药学院 赣州 341000
  • 收稿日期:2013-05-27 修回日期:2013-06-24 发布日期:2013-07-03
  • 通讯作者: 张剑 E-mail:zhangjiangnmc031@163.com
  • 基金资助:

    赣南医学院项目课题(No. YB201014)资助项目.

Progress in the Asymmetric Metal-Catalyzed 1,2-Addition Reactions of Arylboronic Acids with Ketones

Luo Renshi, Liao Jianhua, Zhang Jian   

  1. School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000
  • Received:2013-05-27 Revised:2013-06-24 Published:2013-07-03
  • Supported by:

    Project supported by the Science Foundation of Gannan Medical University (No. YB201014).

A number of biologically active compounds and drugs contain the structural unit of chiral aryl-substituted tertiary alcohol. The catalytic asymmetric arylation of ketones is a powerful tool for the efficient construction of such compounds. Arylboron reagents have attracted considerable attention due to their availability, relative insensitivity to air and moisture, high functional group tolerance and generally low toxicity. Recent progress of the catalytic asymmetric arylation of highly activated ketones such as isatins, trifluoromethyl ketones, α-ketoesters, 1, 2-diketones and unactivated ketones is reviewed.

Key words: metal-catalyzed, arylboronic acid, ketone, asymmetric, 1,2-addition, progress